Year

Main Objectives 

Related Research Activities

2017

I. Synergic pertraction of Cephalosporin C,
6-aminopenicillanic acid,  mupirocin, hyaluronic acid, rosmarinic acid,  pantothenic acid

1. Individual and selective synergic pertraction of Cephalosporin C from pure solution, from simulated and real broths.

2. Individual and selective synergic pertraction of
6-aminopenicillanic acid from pure solution and from real enzymatic media.

3. Synergic pertraction of mupirocin from pure solution, from simulated and real broths.

4. Synergic pertraction of hyaluronic acid from pure solution and from bacterial broths.

5. Synergic pertraction of rosmarinic acid from pure solution, from simulated cultures and  from real cells suspensions.

6. Individual and selective synergic pertraction of pantothenic acid from pure solution and from real broths.

2018

II. Synergic pertraction of
2-ketogluconic acid,  methylbenzylamine and acetophenone

III. Optimization of hybrid systems for fungal products

IV. Optimization of hybrid systems for bacterial products

7. Synergic pertraction of 2-ketogluconic acid from pure solution and from real broths.

8.  Individual synergic pertraction of methylbenzylamine / acetophenone from pure solution.

9. Selective synergic pertraction of methylbenzylamine and acetophenone from pure solution.

10. Selective synergic pertraction of methylbenzylamine and acetophenone from real enzymatic media.

11. Design and construction of hybrid fermentation – synergic pertraction system for production of Cephalosporin C and pantothenic acid. Modelling and optimization of the hybrid system.

12. Design and construction of hybrid fermentation – synergic pertraction system for production of mupirocin, hyaluronic acid, and 2-ketogluconic acid. Modelling and optimization of the hybrid system.

2019

V. Optimization of hybrid systems for cells products

VI. Optimization of hybrid systems for enzymatic products

13. Design and construction of hybrid fermentation – synergic pertraction system for rosmarinic acid. Modelling and optimization of the hybrid system for rosmarinic acid production. 

14.  Design and construction of hybrid fermentation – synergic pertraction  system for production of 6-aminopenicillanic acid and acetophenone. Modelling and optimization of the hybrid system.