SUPERIOR
VALORIZATION OF THE BIOMASS THROUGH RECOVERY OF VALUABLE COMPOUNDS
[BIOEXTR]
Research
programme: PN-III-P1-1.1-TE
Project code: PN-III-P1-1.1-TE-2021-0153
Financing
contract: PN III TE, nr. TE 16 ⁄ 2022
Total Budget:
450.000,00 Ron
Duration:
10/05/2022 - 09.05.2024
Funding
agency: UEFISCDI
Acronym:
BIOEXTR
Project
leader: Associate professor Alexandra Blaga, PhD
In the
project “Superior valorisation of the biomass through recovery of valuable
compounds", that joins the top of the world-wide research on
bio-separation of natural compounds with important applications in medicine,
food and cosmetics research, the separation of some vitamins, carboxylic acids,
carbohydrates and lipids by extraction and pertraction with ionic liquids will
be studied. These extraction techniques offer the advantages of the high
efficiency and selectivity, the reduction of the separation duration, the
reduction of solvent loss, and, in the case of pertraction, the possibility to
transport the solute against its concentration gradient. Using ionic liquids in
extracting bioactive natural compounds from biomass not only leads to a green
process, but also improves the extraction efficiency from a thermodynamic point
of view. Furthermore, these methods can be applied for separating the natural
compounds with thermic and chemical liability. The project will significantly
contribute to the knowledge of the separation mechanism of natural compounds by
non-conventional extraction techniques (reactive extraction, pertraction), to
the quantification of the influence of the main factors on separation
efficiency, to the modelling, optimization and scaling-up of these processes,
in the purpose of improving the technologies applied for these compound's
production.
Project
objective
The BIOEXTR
project aims to develop downstream processes for the separation of vitamins
(vitamin C, vitamin B9), carboxylic acids (adipic acid, muconic acid obtained
from microbial biomass produced using glycerol or lignocellulose substrates),
and carbohydrates and lipids (from Scenedesmus opoliensis or Chlorella
fusca wet microalgae) by extraction and pertraction with ionic liquids.
Obtained
results
The project
has significantly contribute to the knowledge of the separation mechanism of
natural compounds (vitamins, carboxylic acids, lipids) by non-conventional
extraction techniques (reactive extraction, pertraction) using ionic liquids,
to the quantification of the influence of the main factors on separation
efficiency, to the modeling, optimization and scaling-up of these processes at
superior level, in the purpose of the improving of the technologies applied for
these compounds production. Several studies published within this project
represented a world premiere for the separation of vitamins and carboxylic
acids using ionic liquids.
Team:
Project
leader: Associate professor Alexandra Blaga, PhD
Lecturer
Lenuta Kloetzer, PhD
Lecturer
Alexandra Tucaliuc, PhD
Lecturer
Elena Niculina Dragoi, PhD
Alexandra
Maria TANASA (POPA), PhD student
Diana
Georgiana Gal (master student, eng.)
Project Dissemination:
Year 2022
Study on the
separation of vitamins (vitamin C, vitamin B9) using ionic liquids
|
Results |
Planed/Realised |
|
Creation of a
database with scientific information from the literature |
1/1 |
|
Participation in
a scientific event (conference) |
1/3 |
|
Completion of an article
for submission in an ISI Journal |
1/2 |
|
Creation of the
project web page |
1/1 |
Conferences:
S4 – 008
Alexandra Cristina Blaga, Alexandra Tucaliuc, Lenuta Kloetezer - Ionic Liquids for Reactive Extraction of
Biosynthetic Products, RICCCE 2022
S4 – 009
(oral presentation) Alexandra Cristina Blaga, Alexandra Tucaliuc, Lenuta
Kloetezer, Anca Irina Galaction, Dan Cascaval - Synergic Reactive Extraction
Applied for Acidic Compounds Separation, RICCCE 2022
S2-P20.
Separation of biosyntetic products by pertraction using ionic liquids - A.C.
Blaga, L. Kloetzer, A. Tucaliuc, ICCE 2022
Published articles:
Blaga,
A.C.; Tucaliuc, A.; Kloetzer, L. Applications of Ionic Liquids in Carboxylic
Acids Separation. Membranes (Q1) 2022, 12, 771.
https://doi.org/10.3390/membranes12080771
Tucaliuc,
A.; Cîșlaru, A.; Kloetzer, L.; Blaga, A.C. Strain Development, Substrate
Utilization, and Downstream Purification of Vitamin C. Processes (Q2)
2022, 10, 1595. https://doi.org/10.3390/pr10081595
Year 2023
|
Results |
Planed/Realised |
|
Creation of a
database with scientific information from the literature |
1/1 |
|
Participation in
scientific events (conference) |
2/7 |
|
Publication of 2
article in an ISI Journal (Q1/Q2) |
2/2 |
|
Obtaining a patent |
1/2 |
|
Actualization of the
project web page |
1/1 |
Conferences:
- PRM-P02
Green approach for 2-ketogluconic acid separation, Blaga Alexandra Cristina,
Gheorghe Asachi Technical University of Iasi, Romania, 3rd
International Conference On Applied Science & Engineering, Theme:
“Technological Developments & Modern Trends in Applied Science and Advanced
Engineering”, September 25-26 2023, Paris, France
- RO.41.Green reactive extraction process for vitamin B9 separation, Alexandra Cristina Blaga, Lenuta Kloetzer, Dan Cascaval, Anca Irina Galaction, EUROINVENT 2023, Iasi, Romania
- RO.42. 2-Ketogluconic acid separation process using a phosphonium ionic liquid, Alexandra Cristina Blaga, Alexandra Tucaliuc, Anca Irina Galaction, Dan Cascaval, EUROINVENT 2023, Iasi, Romania
- PO.5.1. Eco-process for lipids extraction from microalgae using ionic liquids - Alexandra Cristina Blaga, Lenuta Kloetzer, Alexandra Tucaliuc, International Conference on Environmental Engineering and Management (ICEEM), Iasi, Romania
- PO.5.11 Eco-friendly process for vitamins separation from aqueous solutions - Alexandra Cristina Blaga*, Alexandra Tucaliuc, Lenuta Kloetzer, Anca Irina Galaction, Dan Cascaval, International Conference on Environmental Engineering and Management (ICEEM), Iasi, Romania
- B.2. Modelling And Optimization Of Folic Acid Separation Using Ionic Liquids - Elena Niculina Dragoi, Alexandra Cristina Blaga, Lenuta Kloetzer, Alexandra Tucaliuc, Diana Georgiana Gal, The 18th International Conference of Constructive Design and Technological Optimization in Machine Building Field – OPROTEH, Bacau, Romania
- F.1. Ionic Liquid Mediated Petraction For Vitamin C - Alexandra Cristina Blaga, Lenuța Kloetzer, Alexandra Tucaliuc, Dan Cascaval, Anca Irina Galaction, The 18th International Conference of Constructive Design and Technological Optimization in Machine Building Field – OPROTEH, Bacau, Romania
Published articles:
- Blaga,
A.C.; Dragoi, E.N.;Tucaliuc, A.; Kloetzer, L.; Cascaval, D. - Folic Acid
Ionic-Liquids-Based Separation: Extraction and Modelling. Molecules 2023, 28,
3339.https://doi.org/10.3390/molecules28083339
- Blaga,
A.C.; Gal, D.G.; Tucaliuc, A. - Recent Advances in Muconic Acid Extraction
Process. Appl. Sci. 2023, 13, 11691. https://doi.org/10.3390/app132111691
Patents demand:
Procedeu de separare a vitaminei B9 - Patent application No
A00116/10.03.2023
Procedeu de separare a acidului 2-cetogluconic - Patent application No. A00117/10.03.2023
Year 2024
Studies on
the selective separation of carbohydrates and lipids from wet algae by
extraction with different ionic liquids
|
Nr. |
Indicator |
Planed/Realised |
|
1. |
Creation of a database with
scientific information from the literature |
1/1 |
|
2. |
Participation in scientific events
(conference) |
1/1 |
|
3. |
Publication of 1 article in an ISI
Journal (Q1/Q2) |
1/1 |
|
4. |
Obtaining a patent |
1/1 |
|
5.. |
Actualization of the project web
page |
1/1 |
Conferences:
13th International Conference on Materials Science and Engineering –
BraMat 2024, 13-16.03.2024
III.PO.09. Ionic liquids as green extractants for muconic
acid separation, A.C. Blaga, A. Tucaliuc, L. Kloetzer, E.N. Dragoi
Published articles:
Selective separation of vitamin C by reactive extraction using ionic
liquid: Experimental and modelling, A. C. Blaga, E. N. Dragoi, D. G. Gal, A. C.
Puitel, A. Tucaliuc, L. Kloetzer, D. Cascaval, A. I. Galaction, Journal of
Industrial and Engineering Chemistry 133 (2024) 183–194
https://doi.org/10.1016/j.jiec.2023.11.057
Patent request:
Procedeu de separare a acidului muconic - Patent application No
A00022/26.01.2024
Final report
Contact
Alexandra
Blaga – acblaga@tuiasi.ro